Microbes living in human gut are gaining more attention due to their significant role in human health and disease. We intend to engineer microbiome with exogenous biological pieces to sense, record and/or deliver therapeutic functions.
Microbiome interact extensively with the host. We will explore cell-cell or cell-host interactions for elongated retention or positional colonization of microbiome in gut.
Targeting the existing issues and challenges in protein function reprogramming, we plan to explore signal triggered enzyme functions for best performance of the system.